Registration Dossier
Registration Dossier
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EC number: 245-844-2 | CAS number: 23726-93-4
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
OECD Guideline 209, GLP, key study, validity 1:
3h-NOEC = 32 mg/L;
3h-EC50 = 275 mg/L (95% CI: 214 -339 mg/L).
Key value for chemical safety assessment
- EC50 for microorganisms:
- 275 mg/L
- EC10 or NOEC for microorganisms:
- 32 mg/L
Additional information
To assess the toxicity of the registered substance to microorganisms, one experimental study is available.
This valid study was performed according to OECD Guideline 209 with GLP statement to assess the effect of the registered substance on the respiration rate of activated sludge. The test was carried out under static conditions with the test item concentrations 10, 32, 100, 320 and 1000 mg/L. The respiration rates of the control, reference and test item replicates were measured after a contact time of three hours, and the inhibitory effects of the test and reference item (copper (II) sulphate pentahydrate) were determined in comparison to the control respiration rates. The mean inhibition of respiration for the test item replicates were -3, 2, 12, 53 and 58% at 10, 32, 100, 320 and 1000 mg/L, respectively. The EC50-value for the reference item was 101 mg/L. Under the test conditions, the NOEC of test item is 32 mg/L. The test item is not toxic up to the concentration of 32 mg/L to activated sludge of a municipal sewage treatment plant. The EC10 is 93.9 mg/L (95% CI: 81.5 -108 mg/L) and the EC50 is 275 mg/L (95% CI: 214 -339 mg/L) of the test item.
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