Registration Dossier
Registration Dossier
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EC number: 283-952-1 | CAS number: 84776-27-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinchona officinalis, Rubiaceae.
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Sediment (freshwater)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Sediment (marine water)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
Additional information
The aquatic toxicity of the read across substance quinine hydrochloride to invertebrates was determined experimentally and published by Morrow, 2001. In this publication, the EC50 for Daphnia pulex was determined with a petri-dish bioassay method and a multiwell bioassay method. The EC50 (24 h) of quinine hydrochloride is 28.3 mg/l. According to this, the EC50 of quinine is 25.4 mg/L. The aquatic toxicity to algae was also determined experimentally and published by Moreno-Garrido, 2001. In this publication, the toxicity for green algae Dunaliella salina was determined for 72 h in saltwater. The determined EC50 of the read across substance quinine sulphate is 14.5 mg/L. According to this, the EC50 of quinine is 11.13 mg/L. We conclude that totaquina, which consist of 75 % quinine, has a similar EC50 value for invertebrates and algae.
Conclusion on classification
The experimentally determined LC50/EC50 of the read across substance quinine for invertebrates and algae is > 10 mg/L and furthermore quinine is readily biodegradable. We conclude that the EC50 of totaquina, which consist of 75 % quinine is also > 10 mg/L and further totaquina is readily biodegradable. According to CLP 1272/2008 criteria for acute (short-term) aquatic toxicity, only substance with a toxicity of LC50/EC50<1 mg/L has to be classified. Therefore, quinine is not harmful to aquatic life and does not need to be classified.
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