Registration Dossier
Registration Dossier
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EC number: 284-635-0 | CAS number: 84961-46-6 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Cinnamomum cassia, Lauraceae.
Endpoint summary
Administrative data
Description of key information
Skin sensitisation: sensitising
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Based on an available publication (Klecak, 1985) in which Cassia oil was found to be sensitising in human (4% HMT/RIPT) and guinea pigs (OET) Cassia oil is considered to be a potential skin sensitiser. Additionally, the constituent Cinnamic aldehyde - trans (CAS 14371-10-9), present at a typical concentration of 77%, is currently classified as H317 (Skin Sens. 1). Based on this information Cassia oil is considered to be classified as H317 (Skin Sens. 1) as well and therefore further testing is deemed not required.
Justification for classification or non-classification
Based on the available data on skin sensitising properties the substance needs to be classified for Skin Sensitisation (Skin Sens. 1/ H317) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
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