Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study according to internetional accepted guidelines but not GLP compliant.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Remarks:
reverse phase
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
Test item: 4-chloro-4’-fluorobutyrophenoneCAS No.: 3874-54-2Batch No.: 2607Physical state: liquidColour: yellowish green/ yellowStorage: cool, dry place in a tightly closed container

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
2.84
Temp.:
30 °C
Remarks on result:
other: HPLC method
Details on results:
The value of partition coefficient of 4-chloro-4’-fluorobutyrophenone was determined by Microsoft Office Excel 2007.

Applicant's summary and conclusion