Registration Dossier
Registration Dossier
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EC number: 700-291-0 | CAS number: 1000701-92-7
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Percutaneous toxicokinetic and repeated cutaneous contact studies with ethylene glycol monohexyl ether
- Author:
- Ballantyne B et al.
- Year:
- 2 003
- Bibliographic source:
- J Appl Toxicol 23; 301-314
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
Test material
- Reference substance name:
- Hexylglycol (EGHE)
- IUPAC Name:
- Hexylglycol (EGHE)
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-(hexyloxy)ethanol
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Duration of treatment / exposure:
- - 6 hours per day on 9 days within a period of 11 days
- Frequency of treatment:
- - daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 44, 222, and 444 mg/kgbw
Basis:
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Male and female NZW rabbits received daily epicutaneous doses equivalent to 0, 44, 222, and 444 mg/kgbw on 9 days within a period of 11 days. Applications were for 6 hours with undiluted EGHE under occlusive conditions. Local irritation was observed in all EGHE treated groups. body weights were reduced at 222 and 444 mg/kgbw. At 444 mg/kgbw, food consumption and haematological parameters (erythrocyte count, haemoglobin concentration and haematocrit) were reduced; 2 females died at 444 mg/kgbw.
Applicant's summary and conclusion
- Executive summary:
Hexylglycol is the parent compound and occurs together with the sodium salt of the submission substance identity. For systemic toxicity, the glycol ether is regarded as a worst case as it is a good solvent and most probably taken up in higher percentages than the ionic salt.
Testing of this specific endpoint is additionally advised against for the submission substance because of its corrosive properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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