Registration Dossier
Registration Dossier
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EC number: 700-291-0 | CAS number: 1000701-92-7
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hexyloxyethanol
- EC Number:
- 203-951-1
- EC Name:
- 2-hexyloxyethanol
- Cas Number:
- 112-25-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2-(hexyloxy)ethanol
- Details on test material:
- n-hexylglykol
Purity: no data given
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- activated sludge obtained from a waste water treating plant treating domestic sewage. Concentration 1 g/L dry substance.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 30 min
Test conditions
- Nominal and measured concentrations:
- Nominal concentrations: 519, 775 and 1030 mg/L
- Details on test conditions:
- Preparation of test solutions:
per vessel: Test substance (either 63, 94, or 125 ml), synthetic medium 8 ml, inoculum 50, filled up with dionised water to a volume of 250 ml - Reference substance (positive control):
- yes
- Remarks:
- 3,5 dichlorophenole
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- other: EC20
- Effect conc.:
- 750 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- EC50 (30 min) = 15 mg/L
Applicant's summary and conclusion
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