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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
For justification of read across see category justification attached to category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-(2-butoxyethoxy)ethoxy)ethanol
EC Number:
205-592-6
EC Name:
2-(2-(2-butoxyethoxy)ethoxy)ethanol
Cas Number:
143-22-6
Molecular formula:
CH3(CH2)3(OCH2CH2)3OH
IUPAC Name:
2-[2-(2-butoxyethoxy)ethoxy]ethanol
Constituent 2
Chemical structure
Reference substance name:
3,6,9,12-tetraoxahexadecan-1-ol
EC Number:
216-322-1
EC Name:
3,6,9,12-tetraoxahexadecan-1-ol
Cas Number:
1559-34-8
Molecular formula:
C12H26O5
IUPAC Name:
3,6,9,12-tetraoxahexadecan-1-ol

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Remarks on result:
not determinable due to absence of adverse toxic effects
Remarks:
No effects expected up to limit dose of 1000mg/kgbw/day

Maternal abnormalities

Abnormalities:
no effects observed

Results (fetuses)

Effect levels (fetuses)

Remarks on result:
not determinable due to absence of adverse toxic effects
Remarks:
No effects expected up to limit dose of 1000mg/kgbw/day

Fetal abnormalities

Abnormalities:
no effects observed

Overall developmental toxicity

Developmental effects observed:
no

Any other information on results incl. tables

Current available data from category members suggests no adverse effects would be seen up to the limit dose shown.

There is no data on the toxicity to development for this substance. A testing proposal has been submitted for the substance 2 -(2 -(2 -butoxyethoxy)ethoxy)ethanol or this substance and the results will be read across from one to the other using a category approach.

Applicant's summary and conclusion