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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
For justification of read across see category justification attached to category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-(2-butoxyethoxy)ethoxy)ethanol
EC Number:
205-592-6
EC Name:
2-(2-(2-butoxyethoxy)ethoxy)ethanol
Cas Number:
143-22-6
Molecular formula:
CH3(CH2)3(OCH2CH2)3OH
IUPAC Name:
2-[2-(2-butoxyethoxy)ethoxy]ethanol
Constituent 2
Reference substance name:
205-22-6
IUPAC Name:
205-22-6
Constituent 3
Reference substance name:
2-(2-(2-butoxy)ethoxy)ethanol
IUPAC Name:
2-(2-(2-butoxy)ethoxy)ethanol
Details on test material:
Name of test material (as cited in study report): 2-(2-(2-butoxy)ethoxy)ethanol
Analytical purity: purity 79.5%

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium, other: all strains examined
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Vehicle controls validity:
valid
Positive controls validity:
valid
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
no cytotoxicity
Vehicle controls validity:
valid
Positive controls validity:
valid

Any other information on results incl. tables

Result based on available data from category members and supported by reliable QSAR.

Applicant's summary and conclusion