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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: There are no details on the method available.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
publication
Title:
ALKALOIDS Toxicology
Author:
Wink, M.
Year:
2003
Bibliographic source:
http://de.scribd.com/doc/16524192/ALKALOIDS-Toxicology

Materials and methods

Principles of method if other than guideline:
There are no details on the method available.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Cinchonidine
EC Number:
207-622-3
EC Name:
Cinchonidine
Cas Number:
485-71-2
Molecular formula:
C19H22N2O
IUPAC Name:
cinchonan-9-ol
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Cinchonidine

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 206 mg/kg bw
Based on:
test mat.
Remarks on result:
other: no further information

Applicant's summary and conclusion

Conclusions:
The intraperitoneal LD50 of cinchonidine, tested on rats is 206 mg/kg bw.
Executive summary:

The acute toxicity of cinchonidine was tested via an intraperitoneal injection. The experimental study published by Wink, 2003 showed that the LD50 of cinchonidine, tested on rats is 206 mg/kg bw.