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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The acute oral effects were investigated in rats by observation of the animals for a period of 2 weeks after administration of a single dose.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl enantate
EC Number:
203-382-9
EC Name:
Ethyl enantate
Cas Number:
106-30-9
Molecular formula:
C9H18O2
IUPAC Name:
ethyl heptanoate

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: young adult
- Fasting period before study: 18 hours
- Diet: food was replaced in cages as soon as animals received their respective doses
- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
Highest administered dose: 34640 mg/kg bw.
Unclear whether also lower doses were examined.
No. of animals per sex per dose:
5 male and 5 female rats
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7-14 days
- Frequent observations and weighing: yes
- Necropsy of survivors performed: no
Statistics:
LD50 were computed by the method of Litchfield and Wilcoxon (1949).

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 34 640 mg/kg bw
Based on:
test mat.
Remarks on result:
other: This was the highest dose administered.
Mortality:
No animals died.
Clinical signs:
other: Depression, coma, rough and wet fur.

Any other information on results incl. tables

34640 mg/kg bw was the highest dose administered. The confidence limits were not determined.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 was 34640 mg/kg bw.
Executive summary:

The acute oral toxicity effects of the test substances was assessed in rats. No specific guideline was followed. GLP was not indicated. The LD50, the slope function, and their confidence limits, together with toxic signs and times of death were recorded.

The highest dose administered was 34640 mg/kg bw. The confidence limits were not determined.

No animals died, therefore the acute oral LD50 was calculated to be > 34640 mpg/kg bw.

Observed toxic signs were depression, coma and a rough and wet fur.