Ethyl enantate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1964

Report date:

1964

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The acute oral effects were investigated in rats by observation of the animals for a period of 2 weeks after administration of a single dose.

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl enantate

EC Number:

203-382-9

EC Name:

Ethyl enantate

Cas Number:

106-30-9

Molecular formula:

C9H18O2

IUPAC Name:

ethyl heptanoate

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: young adult
- Fasting period before study: 18 hours
- Diet: food was replaced in cages as soon as animals received their respective doses
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

Highest administered dose: 34640 mg/kg bw.
Unclear whether also lower doses were examined.

No. of animals per sex per dose:

5 male and 5 female rats

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 7-14 days
- Frequent observations and weighing: yes
- Necropsy of survivors performed: no

Statistics:

LD50 were computed by the method of Litchfield and Wilcoxon (1949).

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 34 640 mg/kg bw

Based on:

test mat.

Remarks on result:

other: This was the highest dose administered.

Mortality:

No animals died.

Clinical signs:

other: Depression, coma, rough and wet fur.

Any other information on results incl. tables

34640 mg/kg bw was the highest dose administered. The confidence limits were not determined.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The acute oral LD50 was 34640 mg/kg bw.

Executive summary:

The acute oral toxicity effects of the test substances was assessed in rats. No specific guideline was followed. GLP was not indicated. The LD50, the slope function, and their confidence limits, together with toxic signs and times of death were recorded.

The highest dose administered was 34640 mg/kg bw. The confidence limits were not determined.

No animals died, therefore the acute oral LD50 was calculated to be > 34640 mpg/kg bw.

Observed toxic signs were depression, coma and a rough and wet fur.