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Diss Factsheets

Administrative data

Key value for chemical safety assessment

Genetic toxicity in vitro

Description of key information

Gene mutation in bacteria (OECD 471): Negative

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (negative)

Additional information

The genotoxicity of the test substance Cinnamon bark oil was tested in bacterial strains TA1535, TA1537, TA98 and TA100 and E.coli WP2uvrA according to OECD TG 471 (Ames test). The negative and positive controls were determined to be valid. All the positive control chemicals used in the test induced marked increases in the frequency of revertant colonies, confirming the activity of the S9-mix and the sensitivity of the bacterial strains. Cytoxicity was observed in both experiments by a reduction in growth of the bacterial background lawns, being more apparent in experiment 2 (using pre-incubation methodology). No significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, with any dose test item, either with or without metabolic activation or exposure method.

Justification for classification or non-classification

Based on the results of the Ames test, the substance is not mutagenic and therefore it does not have to be classified for mutagenicity in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).