Registration Dossier
Registration Dossier
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EC number: 210-112-3 | CAS number: 606-28-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23rd October - 11th November 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl 2-benzoylbenzoate
- EC Number:
- 210-112-3
- EC Name:
- Methyl 2-benzoylbenzoate
- Cas Number:
- 606-28-0
- Molecular formula:
- C15H12O3
- IUPAC Name:
- methyl 2-benzoylbenzoate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
- Specific details on test material used for the study:
- Chemical name: methyl-2-benzoylbenzoate
Batch no.: 103189
CAS no.: 606-28-0
EC no.: 210-112-3
Molecular formula: C15H12O3
Molecular mass: 240.3 g/mol
Description: white to light yellowish powder
Purity: 99.6%
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Strain Crl:HanWist(Glx:BRL)BR
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 15% methyl cellulose
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- discriminating dose
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Single oral administration of methyl-2-benzoylbenzoate at a dose level of 2000 mg/kg caused no death in a group of ten fasted rats.
- Clinical signs:
- other: No clinical signs observed.
- Gross pathology:
- No macroscopic changes were observed for animals killed on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Single oral administration of methyl-2-benzoylbenzoate at a dose level of 2000 mg/kg caused no death in a group of ten fasted rats. Accordingly, the discriminating dose was 2000 mg/kg and the acute oral minimum lethal dose of methyl-2-benzoylbenzoate to rats was found to exceed 2000 mg/kg.
- Executive summary:
The acute oral minimum lethal dose of methyl-2-benzoylbenzoate to rats was found to exceed 2000 mg/kg.
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