Registration Dossier
Registration Dossier
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EC number: 211-536-1 | CAS number: 659-70-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Description of key information
No inhibition of the microbial activity up to a substance concentration of 100 mg/L in two biodegradation tests were observed. Therefore, no further test is necessary to evaluate the respiration inhibition of activated sludge. The concentration used in the toxicity control (100 mg/L) can be used as NOEC value to derive the PNEC STP.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
According to the ECHA Guidance document R7b, no further test on the toxicity to microorganisms has to be conducted if the toxicity control in a ready biodegradability test shows no inhibitory effects on microorganisms. As the toxicity control in both the Key and Supporting studies (OECD 301 D, study no. 09-E003 and OECD 301 F, study no. 1999072; section 5.2) showed no inhibition of the microbial activity up to a substance concentration of 100 mg/L, no further test is necessary to evaluate the respiration inhibition of activated sludge. The concentration used in the toxicity control (100 mg/L) can be used as NOEC value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
