Registration Dossier
Registration Dossier
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EC number: 943-007-2 | CAS number: -
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable: >90% in 28 days (OECD 301B); read across
Key value for chemical safety assessment
Additional information
Experimental data investigating the biodegradability of Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) is not available. The assessment was therefore based on a study conducted with the structural analogue substances Isopropyl palmitate (CAS 142-91-6) and Isopentyl laurate (CAS 6309-51-9) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The biodegradability of Isopropyl palmitate (CAS 142-91-6) was investigated in a study according to OECD Guideline 301B (King, 1993). Activated sludge was exposed to the test substance for a period of 28 days. The biodegradation rate was determined by measuring the CO2 evolution in the test vessels. After 28 days, the test substance was degraded by 91.3%. At the end of the 10-day window the substance degradation reached >60 %. Therefore the substance is considered readily biodegradable. A comparable result was determined in a study on the structural analogon Isopentyl laurate (CAS 6309-51-9). The test was conducted according to OECD Guideline 301B (Junghans, 2008). A degradation rate of 100% based on CO2 evolution was determined after 28 days of exposure. The biodegradation of the test item reached 80% at the end of the 10-day window.
Based on the results of the read across studies Fatty acids, C12-18, even numbered, 3-methylbutyl esters (CAS 1314763-50-2) is considered readily biodegradable according to the OECD criteria. The assumption is supported by QSAR calculations (VegaNIC version 1.0.8 using Ready biodegradability model (version 1.0.8)) conducted for the single substance components (Birkhofer, 2015). The calculations predict ready biodegradability for all components and all components are within the applicability domain of the model.
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