Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-345-3 | CAS number: 515851-08-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 004
- Report date:
- 2004
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- N4-[3-(1H-imidazol-1-yl)propyl]-2-methylbenzene-1,4-diamine trihydrochloride
- EC Number:
- 700-345-3
- Cas Number:
- 515851-08-8
- Molecular formula:
- C13H21Cl3N4
- IUPAC Name:
- N4-[3-(1H-imidazol-1-yl)propyl]-2-methylbenzene-1,4-diamine trihydrochloride
- Reference substance name:
- [TN]Kn 172[/TN][SPEC][/SPEC][AM]>99%[/AM]
- IUPAC Name:
- [TN]Kn 172[/TN][SPEC][/SPEC][AM]>99%[/AM]
- Details on test material:
- Kn 172
SAT 030768
Batch No.: Kn-Gi 8634/1
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Controls:
- not required
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 1, 24, 48, 72 hours
- Number of animals:
- 3
Results and discussion
Any other information on results incl. tables
No irritation was observed at treated site following a 4 hour exposure period.
These results indicate that the test item, KN 172, has no irritant effect on the
skin of the rabbit following a 4 hour dermal exposure period.
European Directives concerning the classification, packaging and labelling of dangerous substances and preparations (671548-EEC and subsequent revisions) would indicate the following: Classification : Not required
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification: not irritating
- Executive summary:
The acute dermal imtation of KN 172 was investigated in the rabbit.
A 0.5 g aliquot of the substance was applied to the prepared dorsal skin of 3 animals for a
period of 4 hours. The resulting reaction to treatment was assessed 1, 24, 48 and 72 hours
after the end of the exposure period.
No imtation was observed at treated site following a 4 hour exposure period.
These results indicate that the test item, KN 172, has no irritant effect on the skin of the
rabbit following a 4 hour dermal exposure period.
European Directives conceming the classification, packaging and labelling of dangerous
substances and preparations (671548fEEC and subsequent revisions) would indicate the following:
Classification: Not required
Symbol: None indicated
R-phrase: None indicated
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
