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EC number: 282-468-8 | CAS number: 84229-70-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Allergic dermatosis and respiratory deseases from reactive dyes.
- Author:
- Estlander T
- Year:
- 1 988
- Bibliographic source:
- Contact Dermatitis 1988;18:290-297
Materials and methods
- Type of sensitisation studied:
- respiratory
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Occupational case report
Patch-Test, Scratch- or Prick-Test, RAST - GLP compliance:
- no
Test material
- Reference substance name:
- Reactive Black 5
- IUPAC Name:
- Reactive Black 5
- Details on test material:
- The test substances were 9 commercial dye powders, brought in from the patients.
Analytical investigation revealed different impurities, amongst others 9 µg/g chromium.
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 5
- Sex: 4 male; 1 female
- Age: 24-52 years - Clinical history:
- Exposure to reactive dyes before symptoms developed: 8 months to 4 years
- Controls:
- no data
- Route of administration:
- other: Patch-Test, Scratch-/Prick-Test, RAST
Results and discussion
- Results of examinations:
- Patch test: 4 patients with eczema reacted positively to 9 commercial dye powders
2 patients reacted positive to Remazol Schwarz B (1 to 2% in pet). 1 of them was positive in the scratch or prick tests and nasal provocation test, the other one was negative in the scratch or prick tests and RAST.
Scratch and/or prick test: the 2 patients who also had respiratory symptoms and/or urticaria reacted positively to the same dyes as on patch testing
the 5th patient, who had urticaria and respiratory symptoms, reacted positively to Remazol Gold Gelb RNL, but the patch
test with that dye was negative
Applicant's summary and conclusion
- Executive summary:
5 cases of occupational eczema, urticaria and respiratory disease from reactive dyes, occurring during 1977-1987, are reported. The patients, 4 men and 1 woman, were 24-52 years old when examined. They had been working in dye houses or textile plants, and had been exposed to reactive dyes for 8 months to 4 years before symptoms developed. Only 1 of the patients has been able to continue in the same occupation. On patch testing, the 4 patients with eczema reacted positively to 9 commercial dye powders. 2 patients reacted to the same dye, Remazol Schwarz B. On scratch and/or prick testing, the 2 patients who also had respiratory symptoms and/or urticaria reacted positively to the same dyes as on patch testing. The 5th patient, who had urticaria and respiratory symptoms, reacted positively to a dye, Remazol Gold Gelb RNL, but the patch test with that dye was negative. None of the patients was patch-test-positive to para-phenylenediamine (PPD) or to textile dye allergens in a series of organic dyes. Thus, the series of organic dyes has little value in the screening of allergy to reactive dyes. A 1% pet. dilution of commercial dye powder for patch testing and the same concentration in distilled water for prick testing seem to be suitable for the screening of allergy to reactive dyes.
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