Registration Dossier
Registration Dossier
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EC number: 282-468-8 | CAS number: 84229-70-9
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Screening tests for biodegradation of Reactive Blue 203 and its structural analogues in water showed that the test item is not readily or inherently biodegradable. However, it is rapidly hydrolysed with a half-life of 2 to 6 days at pH 7. When the structural analogue Reactive Black 5 was applied to a sediment/water test system at a final concentration of 1 mg/kg, the test item was rapidly degraded. The DT50of Reactive Black 5 was 2 days. After 3 to 6 days, only 10% of the applied Reactive Black 5 could be found. All metabolites decreased at the end of the test period to levels around the lower level of quantification. Consequently, an accumulation of metabolites could be excluded. The majority of the metabolites of Reactive Black 5 were deposited in form of non-extractable residues in sediment during test phase. After about 1 month, mineralization of the metabolites started.
It is therefore expected that Reactive Blue 203 is rapidly removed from the environment by abiotic degradation and does not persist in the environment.
Based on data from the structural analogues, Reactive Blue 203 has a log Kow of <-4.3. This value indicates that possible bioaccumulation in the food chain is not anticipated. A bioaccumulation study in the carp with the structural analogue Reactive Black 5, revealed bioconcentration factors < 11 for 0.2 mg/L and < 1.1 for 2 mg/L. Hence, Reactive Black 5 and consequently Reactive Blue 203 do not bioaccumulate in the aquatic compartment. Based on data from kinetic and metabolism studies in rats (oral and intravenous administration), Reactive Black 5 does not have any bioaccumulation potential in animals. Due to the very low toxicity, rapid degradation and lack of bioaccumulative properties, secondary poisoning can be excluded for Reactive Blue 203.
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