Registration Dossier
Registration Dossier
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EC number: 246-467-6 | CAS number: 24801-88-5
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low octanol water partition coefficient and the adsorption potential of this substance is related to this parameter
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- See attached QMRF/QPRF
- Principles of method if other than guideline:
- The method has been developed specifically for organosilicon compounds. It is a linear regression based model. The descriptors are the log Kow and an indicator variable for the presence of an amine. See QMRF and QPRF for further details.
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- -0.6 dimensionless
- pH:
- 7
- Temp.:
- 20 °C
- Remarks on result:
- other: Predicted for the silanol hydrolysis product 3 -aminopropylsilanetriol
- Conclusions:
- A predicted log Koc value of -0.6 at 20°C and pH 7 was determined for the silanol hydrolysis product of the submission substance using a relevant estimation method. The result is considered to be reliable.
Referenceopen allclose all
Description of key information
Adsorption/desorption:
log Koc [triethoxy(3-isocyanatopropyl)silane]: not relevant due to very rapid hydrolysis in contact with water
log Koc [3-aminopropyl(triethoxy)silane]: not relevant due to rapid hydrolysis in contact with water
log Koc [3-aminopropylsilanetriol]: -0.6 at 20°C and pH 7 (QSAR)
Key value for chemical safety assessment
Additional information
Triethoxy(3-isocyanatopropyl)silane hydrolyses very rapidly (half-life < 5 minutes at pH 7) to form 3-aminopropyltriethoxysilane (hydrolysis of isocyanate group), and carbon dioxide.
3-Aminopropyl(triethoxy)silane hydrolyses rapidly (8.5 hours at pH 7) to the final hydrolysis product, 3-aminopropylsilanetriol and ethanol. Both hydrolysis products have low log Kow values (<3) and thus have low potential for adsorption and the requirement for testing is waived. In view of this hydrolysis rate, risk assessment for the registered substance is carried out for the silanol hydrolysis product, 3-aminopropylsilanetriol and ethanol.
The log Koc of the silanol hydrolysis product, 3-aminopropylsilanetriol has been predicted using a validated QSAR estimation method to be-0.6 at 20°C and pH 7.
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