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EC number: 609-915-5 | CAS number: 4136-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Oct - Nov 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1 alpha-Methyl-4-androstene-3,17-dione
- EC Number:
- 609-915-5
- Cas Number:
- 4136-62-3
- Molecular formula:
- C20 H28 O2
- IUPAC Name:
- 1 alpha-Methyl-4-androstene-3,17-dione
- Details on test material:
- - Name of test material (as cited in study report): 1-Alpha-Methylandrostendion
- Analytical purity: 98.7%
- Lot/batch No.: 1365
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 27.1 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Table 1: Cumulative immobilization.
Dilution/concentration of ZK 62096 (mg/L) | 24 hours | 48 hours |
Control (tap water) / 0 | 0 | 0 |
1 :16 / 3,5 | 0 | 0 |
1:8 / 6,3 | 1 | 1 |
1:4 / 11,3 | 2 | 3 |
1:2 / 22,0 | 2 | 2 |
Saturated solution / 33,4 | 5 | 20 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50/48 hours of 1-Alpha-Methylandrostendion to Daphnia magna could not be calculated. According to the guideline, the EC50 can be
estimated approximately by the geometric mean of the concentration 22.0 and 33.4 mg/L, which was 27.1 mg/L. The highest concentration with no substance-related effects was 22 mg/L. Accordingly, the compound is slightly toxic to Daphnia magna, since the EC50 was between 10 and
100 mg/L. - Executive summary:
The purpose of the study was to determine the acute toxicity (immobilization, EC50/48 hours) of 1 -Alpha-Methyandrostendion with Daphnia magna in order to evaluate the aquatic toxicity. 1 -Alpha-Methyandrostendion is an intermediate of the synthesis of mesterolone. The study was conducted as a definitive test according to the following guideline of the OECD, no 202.
20 juvenile Daphnia magna were used for each test solution of and 20 for the tap water control. The Daphnia were exposed for aperiod of 48 hours under static conditions. Immobilization was recorded at 24 hours and 48 hours. For the preparation of the test solutions a suspension with a nominal loading of 100 mg/L was kept for approximately 30 min in an ultrasonic bath and stirred for 24 hours. This suspension was filtered through a glassfibre filter. The resulting solution served as the highest concentration (saturated solution). It was further diluted 1 :2, 1 :4, 1:8 and 1: 16.
Sampies for the concentration analysis by TOC measurement were taken at 0 and 48 hours after start of exposure. The concentrations were calculated on the basis of the molecular formula. Results gave mean concentrations of 33.4 mg/L (saturated solution), 22.0 mg/L (1:2 solution), 11.3 mg/L (1:4 dilution), 6.3 mg/L (1:8 dilution) and 3.5 mg/L (1 :16 dilution).
Immobilized Daphnia were observed in the dilutions 1:8 up to the saturated solution. The saturated solution was a clear effect level, while at lower concentrations (6.3 to 22.0 mg/L) the lack of a clear exposure-effect relationship suggested that probably some Daphnia were immobilized spontaneously. 1-Alpha-Methylandrostendion is slightly toxic to Daphnia magna, since the EC50 was between 10 and 100 mg/L.
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