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EC number: 942-710-1 | CAS number: -
Acute oral tox
> 2000 mg/kg
No adverse effects.
Red / orange urine and faeces for up to 5 days post treatment.
Some skin and mucous membrane discolouration, but may be from indirect contact with urine/faeces.
Acute dermal tox
No direct testing but assessment based on similar substances indicate no adverse effects
Skin discolouration noted, persisting for the duration of observations in some cases.
Grooming may have led to oral exposure in some cases
No direct evidence of absorption.
In-vivo testing performed for non-EU regulatory processes; no significant effects
Slight discolouration of iris quickly resolved
In-vivo testing performed for non-EU regulatory processes; maximised Guinea pig study positive.
Some dermal absorption is assumed.
Tests on bacterial and mammalian cells were conducted at up to the maximum recommended concentrations with no evidence of cyto-toxicity or mutagenic potential.
The present of S-9 metabolic fraction had no impact on the findings; this does not mean that there is no metabolic process, but that any direct metabolites are similarly non-biologically active.
NOAEL 100 mg/kg/day
The NOAEL is based on maximum dose level of 1000 mg/kg/day.
Red / orange staining of urine and discoloured kidneys is evidence of absorption, distribution and excretion.
No significant biodegradation
This endpoint can indicate aerobic metabolic processes by eukaryotic cells. The absence of apparent effects suggest that there could be a low rate of metabolism, and it is probably that excretion in urine is the main route of elimination.
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