Registration Dossier
Registration Dossier
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EC number: 218-620-7 | CAS number: 2206-94-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A Buehler test was conducted in guinea pigs, to determine the sensitisation potential of the test material after repeated topical applications (PSL, 2003). The undiluted substance was applied topically, on the skin of 20 healthy guinea pigs, three times a week, for a three week induction period. Nine days after the first induction dose, a challenge dose of the test substance at its highest non-irritating concentration (100%) was applied to a naive site on each guinea pig. Approximately 24 and 48 hours after induction and challenge dose, the animals were scored for erythema. A similar induction and challenge application regimen with HCA in mineral oil was followed using an additional ten guinea pigs that served as concurrent positive controls for the study. Two naive control groups were maintained under identical environmental conditions and treated with the test or the positive control substance at challenge only.
Migrated from Short description of key information:
The test material was found to not be sensitising to skin in the Buehler method, in a study conducted according to OECD TG 406 and in compliance with GLP (PSL, 2003).
Justification for selection of skin sensitisation endpoint:
The study was conducted according to current guideline and in compliance with GLP.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data, α-methylenebenzyl acetate does not require classification for sensitisation according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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