Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to the Limit test described in OECD TG403. Restriction: purity of TS not reported; concentration analytically not verified, no data on clinical signs or necropsy.

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: List V.
Author:
Smyth HF, Carpenter CP, Weil CS, Pozzani U
Year:
1954
Bibliographic source:
Arch Ind Hyg Occ Med 10: 61-68

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
no
Principles of method if other than guideline:
Toxic effects in rats after inhalation exposure for 4 h
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl vinyl ether
EC Number:
203-860-7
EC Name:
Butyl vinyl ether
Cas Number:
111-34-2
Molecular formula:
C6H12O
IUPAC Name:
1-(ethenyloxy)butane
Details on test material:
butyl vinyl ether, no further data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
Male and female Carworth-Wistar rats were used, 90 to 120 g in weight. Animals were kept on complete diet.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: air
Details on inhalation exposure:
Metered atmospheres were generated by using pumps which delivered known amounts of TS to a stream of air. Concentrations are nominal, but not analytically verified; no further details
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
8000 or 16000 ppm corresponding to 33.3 or 66.6 mg/L
No. of animals per sex per dose:
6 rats
Details on study design:
Groups of 6 male or female rats were used. Mortalities noted during the 14-day observation period. Effect levels related to male and female rats combined.

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC0
Effect level:
8 000 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: (33.3 mg/L) 0 out of 6 rats died
Sex:
male/female
Dose descriptor:
LC100
Effect level:
16 000 ppm
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: (66.6 mg/L) 6 out of 6 rats died
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 33.3 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Recommended limit concentration according to OECD TG403 is 5 mg/L
Mortality:
no further details
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Conclusions:
No mortality was noted (0/6 animals died) in male and female Wistar rats following exposure to 8000 ppm (=33.3 mg/L) for 4 hours and a post exposure observation period of 14 days. However, a dose level of 16000 ppm (66.6 mg/L) for 4 h killed all 6 rats.
The LC50 (4) in rats is >33.3 mg/L (Limit dose according to OECD TG403 ist 5 mg/L).