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Diss Factsheets

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets scientific standards

Data source

Reference
Reference Type:
publication
Title:
Depletion of glutathione and hepato-toxicity caused by vinyl ethers in mice
Author:
Isobe M, Sone T, Takabatake E
Year:
1995
Bibliographic source:
J Toxicol Sci 20: 161-164

Materials and methods

Type of study / information:
Hepatotoxicity
Principles of method if other than guideline:
Hepatotoxicity in mice after i.p. injection
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyl vinyl ether
EC Number:
203-860-7
EC Name:
Butyl vinyl ether
Cas Number:
111-34-2
Molecular formula:
C6H12O
IUPAC Name:
1-(ethenyloxy)butane
Details on test material:
butyl vinyl ether
no further data

Results and discussion

Any other information on results incl. tables

No effects on hepatic non-protein sulfhydryl content.

No effects on serum glutamate pyruvate transaminase activty.

Applicant's summary and conclusion

Conclusions:
No hepatotoxic effects under the limited experimental conditions in this study (one dose, only 1 h post exposure observation time).