Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
March 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EpiOcularTM Eye Irritation Test (OCL-200-EIT).
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Trizinc bis[hexacyanidocobaltate] dodecahydrate
EC Number:
942-358-9
Cas Number:
69207-66-5
Molecular formula:
Zn3[Co(CN)6]2 ·12H2O
IUPAC Name:
Trizinc bis[hexacyanidocobaltate] dodecahydrate
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Any other information on results incl. tables

Determined viability of culture treated by Zinc Hexacyanocobaltate (67.6%) fulfilled the criteria for non-irritancy.

Therefore the test item Zinc Hexacyanocobaltate is considered to be non-irritant to the eye.

The tissue viability met the acceptance criterion (mean OD of negative control was 1.384).

The viability of culture treated by positive control methyl acetate was 29.1%. The positive control met the acceptance criterion: mean tissue viability less than 60%. The viability of culture treated by Zinc Hexacyanocobaltate was 67.6%.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the results of the study, the test item Zinc Hexacyanocobaltate according to Evaluation criteria and Acceptance criteria is considered to be Non-irritant (NI) (the test item-treated tissue viability is > 60% relative to negative control-treated tissue viability).