Registration Dossier
Registration Dossier
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EC number: 942-835-1 | CAS number: -
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The test substance, Triethylenetetramine, propoxylated, TK 10406, was evaluated for genotoxic potential in the standard bacterial reverse mutation test which provided a positive result. Further testing in the mammalian cell gene mutation in vitro as well as in the in vitro mammalian chromosomes aberration test resulted in negative result and therefore following th EU REACh requirement for mutagenicity it was concluded that No genotoxic classification is required.
Justification for selection of genetic toxicity endpoint
All three existing in vitro studies are considered as key value for the chemical safety assessment.
Short description of key information:
Triethylenetetramine, propoxylated, TK 10406 as evaluated for genotoxic potential in the standard bacterial reverse mutation test, in the mammalian cell gene mutation in vitro as well as in the in vitro mammalian chromosomes aberration test. The results were positive for the Ames test and negative for the two in-vitro mammalian tests.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the above stated assessment of the genotoxic potential of Triethylenetetramine, propoxylated, TK 10406,
(Ames test positive ,in vitro mammalian cell gene mutation test negative, in vitro mammalian chromosomes aberration test negative), the substance is deemed non-genotoxic and accordingly does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and according CLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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