Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 238-513-9 | CAS number: 14507-49-4
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Referenceopen allclose all
- Reference Type:
- other: Predicted data
- Title:
- No information
- Author:
- Gedeon Richter Plc. Health and Safety Department
- Year:
- 2 015
- Bibliographic source:
- QSAR Toolbox 3.1.0.21
- Reference Type:
- other: Predicted data
- Title:
- No information
- Author:
- Gedeon Richter Plc. Health and Safety Department
- Year:
- 2 015
- Bibliographic source:
- VegaNIC - Vega Non - Interactive Client - version 1.0.8
- Reference Type:
- other: Predicted data
- Title:
- No information
- Author:
- Gedeon Richter Plc. Health and Safety Department
- Year:
- 2 015
- Bibliographic source:
- T.E.S.T. version 4.1
- Reference Type:
- other: Predicted data
- Title:
- No information
- Author:
- Gedeon Richter Plc. Health and Safety Department
- Year:
- 2 015
- Bibliographic source:
- ChemProp - QSAR 6 Public OSIRIS Edition
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 13-ethyl-3-methoxygona-2,5(10)-dien-17β-ol
- EC Number:
- 238-513-9
- EC Name:
- 13-ethyl-3-methoxygona-2,5(10)-dien-17β-ol
- Cas Number:
- 14507-49-4
- Molecular formula:
- C20H30O2
- IUPAC Name:
- (1S,3aS,3bR,9bS,11aS)-11a-ethyl-7-methoxy-1H,2H,3H,3aH,3bH,4H,5H,6H,9H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-ol
Constituent 1
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.39 mg/L
- Nominal / measured:
- estimated
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Software Database / Method Endpoint Test duration Species Predicted value QSAR Toolbox Aquatic OASIS LC50 96 h Pimephales promales 0.739 mg/l VegaNIC N.A. LC50 96 h Fathead minnow 0.58 mg/l T.E.S.T. Consensus method LC50 96 h Fathead minnow 0.49 mg/l T.E.S.T. Hiearchical Clustering Method LC50 96 h Fathead minnow 0.48 mg/l T.E.S.T. Group Contribution Method LC50 96 h Fathead minnow 0.3 mg/l T.E.S.T. FDA method LC50 96 h Fathead minnow 0.11 mg/l ChemProp Martin and Young model LC50 96 h Fathead minnow 0.04 mg/l Inferental result 0.39 mg/l
Applicant's summary and conclusion
- Conclusions:
- According to (Q)SAR modells: QSAR Toolbox, VegaNIC, T.E.S.T., ChemProp the predicted values indicated that gonol is hazardous to fishes. The result meets the requirement of Aquatic Acute Category 1.
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