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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: In accordance with column 2 of REACH Annex VIII, the study does not need to be provided (as two other routes are provided). However, the available results are given to support the waiving.

Data source

Reference
Reference Type:
publication
Title:
Range finding toxicity data: List V
Author:
Smyth Jr.HF, Carpenter CP, and Weil CS
Year:
1954
Bibliographic source:
Archives of Industrial Hygiene and Occupational Medicine 4: 119-122

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl benzoate
EC Number:
202-284-3
EC Name:
Ethyl benzoate
Cas Number:
93-89-0
Molecular formula:
C9H10O2
IUPAC Name:
ethyl benzoate
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
other: Carworth-Wistar
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Mellon Institute of Industrial Research, Universitiy of Pittsburgh
- Weight at study initiation: 90-120 g
- Fasting period before study: none

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
TEST ATMOSPHERE
- Brief description of analytical method used: only nominal concentrations are given, no analytical measurement
- Samples taken from breathing zone: no


Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
saturated vapour
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
Statistics:
not required

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
other: concentrated vapour (approaching saturation)
Based on:
test mat.
Exp. duration:
8 h
Mortality:
no mortality observed
Clinical signs:
other: no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A study was conducted on rats to identify the acute toxicity after inhalation of ethyl benzoate. Rats were exposed to concentrated vapour for 8 hours and no deaths occured, therefore the LD50 lies over the saturated vapour concentration of the test substance.
Executive summary:

Among other substances, Ethyl benzoate was tested for its acute toxicity after inhalation in rats. Therefore, female Carworth-Wistar rats were exposed to concentrated vapour of the test substance for 8 hours. As no deaths occured, it was concluded that the LD50 lies over the saturated vapour concentration of the test substance.

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