Ethyl benzoate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Remarks:

Well documented publication, the described study is conducted equivalent or similar to an OECD Guideline.

Data source

Reference

Reference Type:

publication

Title:

Toxicity studies on benzyl benzoate and related benzyl compounds

Author:

Graham BE and Kuizenga MH

Year:

1945

Bibliographic source:

Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 358, 1945.

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl benzoate

EC Number:

202-284-3

EC Name:

Ethyl benzoate

Cas Number:

93-89-0

Molecular formula:

C9H10O2

IUPAC Name:

ethyl benzoate

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: 24-48 hours

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

After preliminary orientation tests, four groups of three rabbits each were used in the range of LD50 +/- 0.5 g/kg bw.

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data

Statistics:

no data

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

2 630 mg/kg bw

Based on:

test mat.

Clinical signs:

other: other: Signs of central nervous stimulation and prostration (12-24 hours) were observed in the rabbits before death.

Gross pathology:

no data

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

Ethyl benzoate was administered to rabbits by gavage in three concentrations. As a result, the LD50 value was found to be 2630 mg/kg bw in rabbits.

Executive summary:

In this publication, a study is described which was conducted to assess the oral toxicity of ethyl benzoate in several animals including rabbits. Ethyl benzoate was administered to a total of 12 rabbits by gavage. Four rabbits each were exposed to one of three concentrations. These concentrations were in the range of the LD50 value +/- 0.5 g /kg bw determined by a preliminary toxicity study. As a result, the LD50 value was found to be 2630 mg/kg bw in rabbits.