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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well documented publication, the described study is conducted equivalent or similar to an OECD Guideline.

Data source

Reference
Reference Type:
publication
Title:
Toxicity studies on benzyl benzoate and related benzyl compounds
Author:
Graham BE and Kuizenga MH
Year:
1945
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 358, 1945.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Fasting period before study: 24-48 hours

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
After preliminary orientation tests, four groups of three rabbits each were used in the range of LD50 +/- 0.5 g/kg bw.
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
Statistics:
no data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 630 mg/kg bw
Based on:
test mat.
Clinical signs:
Signs of central nervous stimulation and prostration (12-24 hours) were observed in the rabbits before death.
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Ethyl benzoate was administered to rabbits by gavage in three concentrations. As a result, the LD50 value was found to be 2630 mg/kg bw in rabbits.
Executive summary:

In this publication, a study is described which was conducted to assess the oral toxicity of ethyl benzoate in several animals including rabbits. Ethyl benzoate was administered to a total of 12 rabbits by gavage. Four rabbits each were exposed to one of three concentrations. These concentrations were in the range of the LD50 value +/- 0.5 g /kg bw determined by a preliminary toxicity study. As a result, the LD50 value was found to be 2630 mg/kg bw in rabbits.