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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions
Remarks:
Well documented publication, the described study is conducted equivalent or similar to an OECD Guideline.

Data source

Reference
Reference Type:
publication
Title:
Toxicity studies on benzyl benzoate and related benzyl compounds
Author:
Graham BE and Kuizenga MH
Year:
1945
Bibliographic source:
Journal of Pharmacology and Experimental Therapeutics. Vol. 84, Pg. 358, 1945.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl benzoate
EC Number:
202-284-3
EC Name:
Ethyl benzoate
Cas Number:
93-89-0
Molecular formula:
C9H10O2
IUPAC Name:
ethyl benzoate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Fasting period before study: 24-48 hours

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
After preliminary orientation tests, four groups of three rabbits each were used in the range of LD50 +/- 0.5 g/kg bw.
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
Statistics:
no data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 630 mg/kg bw
Based on:
test mat.
Clinical signs:
other: other: Signs of central nervous stimulation and prostration (12-24 hours) were observed in the rabbits before death.
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Ethyl benzoate was administered to rabbits by gavage in three concentrations. As a result, the LD50 value was found to be 2630 mg/kg bw in rabbits.
Executive summary:

In this publication, a study is described which was conducted to assess the oral toxicity of ethyl benzoate in several animals including rabbits. Ethyl benzoate was administered to a total of 12 rabbits by gavage. Four rabbits each were exposed to one of three concentrations. These concentrations were in the range of the LD50 value +/- 0.5 g /kg bw determined by a preliminary toxicity study. As a result, the LD50 value was found to be 2630 mg/kg bw in rabbits.