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Ecotoxicological information

Short-term toxicity to fish

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Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
no
Specific details on test material used for the study:
None
Analytical monitoring:
no
Details on sampling:
Not available
Vehicle:
not specified
Details on test solutions:
None
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
TEST ORGANISM
- Common name: Rainbow Trout
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
pH 7-8
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
0.2, 2, 100 and 200 mg/L
Details on test conditions:
No data
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
other: TL0
Effect conc.:
0.2 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Duration:
48 h
Dose descriptor:
other: TL50
Effect conc.:
1.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL100
Effect conc.:
20 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
None
Results with reference substance (positive control):
None
Reported statistics and error estimates:
No data
Sublethal observations / clinical signs:

No mortality was seen with the test concentration 0.2 mg/L. While 5 out of 8 fish were found dead when exposed to 2 mg/l. At 20 and 100 mg/L, all the fish exposed were found dead.

Validity criteria fulfilled:
not specified
Conclusions:
The 48 h LC50 was found to be 1.3 mg/L.
Executive summary:

The short term toxicity of FAT 20077/A was evaluated in a study conducted using methodology similar OECD Guideline 203. Three groups of containing 8 fish each were exposed to test concentrations of 0.2, 2, 20 and 100 mg/L for 48 hours. No mortality was seen with the test concentration 0.2 mg/L. While 5 out of 8 fish were found dead when exposed to 2 mg/l. At 20 and 100 mg/L, all the fish exposed were found dead. Based on these findings, the following results were obtained:

TL0 (48 h): 0.2 mg/L

TL50 (48 h): 1.3 mg/L

TL100 (48 h): 20 mg/L

Description of key information

The short term toxicity of FAT 20077/A was evaluated in a study conducted using methodology similar OECD Guideline 203. Three groups of containing 8 fish each were exposed to test concentrations of 0.2, 2, 20 and 100 mg/L for 48 hours. No mortality was seen with the test concentration 0.2 mg/L. While 5 out of 8 fish were found dead when exposed to 2 mg/l. At 20 and 100 mg/L, all the fish exposed were found dead. Based on these findings, the following results were obtained:

TL0 (48 h): 0.2 mg/L

TL50 (48 h): 1.3 mg/L

TL100 (48 h): 20 mg/L

In couple of supporting studies evaluating short term toxicity to fish, the 48 H TL50 obtained were 3.2 and 4.4 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1.3 mg/L

Additional information