Registration Dossier
Registration Dossier
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EC number: 915-334-0 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
Since no studies investigating the long-term toxicity of Reaction
mass of octadecyl heptanoate and octadecyl octanoate (List No.
915-334-0) to aquatic invertebrates are available, in accordance to
Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the
structurally related source substance Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) was conducted. The read-across substance is
representative to evaluate the long-term toxicity of Reaction mass of
octadecyl heptanoate and octadecyl octanoate (target substance) to
aquatic invertebrates.
The
target substance is a multi-constituent substance specified by mainly C7
and C8 linear fatty acids esterified with a linear alcohol of a chain
length of C18. The source substance Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) is an UVCB substance predominantly consisting of
esters with a C8-C10 fatty acid and a C12-C14 alcohol moiety. A detailed
analogue approach justification is provided in the technical dossier
(see IUCLID Section 13). The source substance has a similar structure
and is suitable for read across to the target substance. In this case of
read-across, the best suited (highest degree of structural similarity,
nearest physico-chemical properties) read-across substance was used for
the assessment.
The
study with the read-across substance Fatty acids, C8-10, C12-18-alkyl
esters (CAS 95912-86-0) was performed according to OECD 211 (GLP;
Salinas, 2013). Daphnia magna was exposed to a nominal loading rate of
10 mg/L (Water Accommodated Fraction). Chemical analysis of the test
substance concentrations was not possible since no suitable analytical
method could be developed to detect the test substance. No effects on
reproduction of D. magna were observed up to the water solubility limit
(< 0.05 mg/L) resulting in a NOELR (21 d) ≥ 10 mg/L.
Based on the results from one structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a comparable structure, it can be concluded that Reaction mass of octadecyl heptanoate and octadecyl octanoate will not exhibit chronic effects to aquatic invertebrates up to the limit of water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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