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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Both the oral and dermal toxicity of the registered substance were determined to be greater than 2000 mg.kg bw.  As such, the registered substance is not considered classifiable for acute toxicity according to the EC regulations 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
This study is a guideline study with a Klimisch score of 1 (reliable withiout restriction)

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Additional information

The registered substance was not lethal by the dermal route of administration in male and female rats at a dose level of 2000 mg/kg. The test item did not cause any systemic toxic effect, and no specific organs for toxicity were identified. The test item was slightly irritating to the exposed skin, however the irritation was reversible.

The registered substance was not lethal by the oral route of administration in female rats at a dose level of 2000 mg/kg. The test item did not cause any systemic toxic effect, and no specific organs for toxicity were identified.

No acute toxicity studies by any other route are available for the registered substance.


Justification for selection of acute toxicity – oral endpoint
Only study available which also meets the appropriate test guideline. Note: The actual value of LD50 for this study is greater than 2000 mg/kg bw

Justification for selection of acute toxicity – inhalation endpoint
See waiver for acute inhalation endpoint in section7.2.2.

Justification for selection of acute toxicity – dermal endpoint
Only study available which also meets guidelines. Note: Actual value of LD50 for this study is greater than 2000 mg/kg bw

Justification for classification or non-classification

Based on the results of the oral and dermal studies according to the EC regulations 1272/2008 and subsequent regulations on classification, labelling and packaging of substances and mixtures, the registered substance does not require classification.