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Diss Factsheets

Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2013-02-07 to 2013-02-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Substance ID is adequately specified with isomers composition. Therefore full validation applies.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. QA statement)
Remarks:
inspection 10/07/2012, signature 30/11/2012
Type of method:
gas saturation method
Key result
Temp.:
25 °C
Vapour pressure:
0.236 Pa
Remarks on result:
other: extrapolated

Average of vapour pressure (mean of three determinations (three flow rates)):

0.962 Pa at 40°C

2.29 Pa at 50°C

5.16 Pa at 60°C

Detailed data, the vapour pressure curve and the regression parameters are provided in the experimental report.

Validation

The linearity of the detector response with respect to concentration was assessed over the concentration range of 10.2 to 102 mg/L (n=5). This was satisfactory with a correlation coefficient of 0.999 being obtained.

Concentrations of sample solutions from traps 1 range between 24 and 55 mg/L (no substance detected in traps 2), therefore within the calibration range.

Discussion

To ensure saturation control, three different flow rates were used at each temperature. From the data, it can be clearly seen that higher flow rates did not lead to lower vapour pressures, which means that the nitrogen was saturated with test item under the conditions of the test. From typical chromatograms of standard and sample, it should be noted that the composition of the vapour phase differs from the test substance: in the standard (i.e. test substance), the major peak eluting at ca 6.13 min is twice as high than the second major peak eluting at ca 5.96 min, while in the sample (i.e. vapour phase), both have the same height. This means the major component is slightly less volatile than the other one.

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured under GLP according to OECD 104 / EU A4 guideline, gas saturation method. Determinations were conducted at 40, 50 and 60°C, with three flow rates per temperature. Mass of evaporated test item was quantified by GC. Vapour pressure at 25°C was extrapolated to be 0.236 Pa from the regression, and the major component was observed to be slightly less volatile than the second one (isomer).

Description of key information

Extrapolated result from experimental measurement.

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
0.236 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study. The result is retained as key data.

It should be noted that a slight variation could be observed within the isomers composition range, the major component being observed to be slightly less volatile than the second one (isomer).