Registration Dossier
Registration Dossier
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EC number: 202-223-0 | CAS number: 93-15-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- 1h exposure, poorly documented
- GLP compliance:
- no
- Test type:
- traditional method
- Limit test:
- no
Test material
- Reference substance name:
- 4-allylveratrole
- EC Number:
- 202-223-0
- EC Name:
- 4-allylveratrole
- Cas Number:
- 93-15-2
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 1,2-dimethoxy-4-(prop-2-en-1-yl)benzene
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Purity of each material was checked in the Organic Chemicals Synthesis Laboratory, AEQI, in Beltsville by gas chromatography: > 98%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150-240 g
- Fasting period before study: 16 hr before dosing.
- Housing: Individually in suspended wire-mesh cages.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Duration of exposure:
- 1 h
- Concentrations:
- 4.8 mg/L
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 4.8 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 1 h
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 was determined to be >4.8 mg/L air after 1h exposure to aerosol in rats.
- Executive summary:
Ten rats, caged separately to minimize filtration of inspired air by animal fur, were exposed for one hour to the aerosol generated from the undiluted test material by a pneumatic nebulizer. The average nominal concentrations of aerosol, the maximum attainable with the experimental equipment, were calculated by dividing the weight lost from the nebulizer by the total volume of air used (in milligrams per liter air) and it results to be 4.8 mg/L air. Following exposure, the animals were observed for 14 days. The LC50 was determined to be >4.8 mg/L air after 1h exposure to aerosol in rats.
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