Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 288-107-0 | CAS number: 85650-96-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented, scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Hydrogen [29H,31H-phthalocyaninesulphonato(2-)-N29,N30,N31,N32]cuprate(1-), compound with (Z)-octadec-9-enylamine (1:1)
- EC Number:
- 288-107-0
- EC Name:
- Hydrogen [29H,31H-phthalocyaninesulphonato(2-)-N29,N30,N31,N32]cuprate(1-), compound with (Z)-octadec-9-enylamine (1:1)
- Cas Number:
- 85650-96-0
- Molecular formula:
- C32 H15 Cu N8 O3 S .C18 H37 N .H
- IUPAC Name:
- Hydrogen [29H,31H-phthalocyaninesulphonato(2-)-N29,N30,N31,N32]cuprate(1-), compound with dodecylamine
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The animals were offered a standardized animal laboratory diet. Food depreviation about 15 - 20 h before study start.
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- 0.5% aqueous carboxymethyl cellulose preparation
Form of application: suspension
Concentrations used: 2, 7 and 20% (G/V)
Application volume: 10 ml/kg - Doses:
- 200, 700 and 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 700 mg/kg bw
- Mortality:
- 200 mg/kg: no deaths after 14 days; 700 and 2000 mg/kg: 10/10 after 14 days
- Clinical signs:
- Dyspnea, apathy, abnormal position, staggering, tremors, spastic gait, tonic and clonic convulsions, skin blue, urine turquoise and blue, ruffled fur, exsiccosis, adhesion of eyelids, poor general state
- Body weight:
- Mean body weight male animals: 25.3 g at study start, 29.2 g after 13 days
Mean body weight female animals: 23.7 g at study start, 25.6 g after 13 days - Gross pathology:
- Animals that died: intraabdominal precipitates of the test substance and coloration
Sacrificed animals: intraabdominal incorporations of the test substance
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
