Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V
GLP compliance:
yes

Test animals

Species:
other: Rat (CD)

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: 1% w/v aqueous methylcellulose
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
There was systemic response to treatment in any animal.
Gross pathology:
Effects on organs:
No abnormalities were noted in any animal at macroscopic
examination at study termination on day 15.
Other findings:
Signs of toxicity (local):
There were no deaths during the study. After bandage
removal a small area of scab formation was noted in two
males and one female, also for two other females, one at day
6 and another at day 8. These reactions had all resolved
by day 11. In addition a very slight irritation was
observed in two females on day 3. These reactions had
resolved by day 4.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU