Registration Dossier
Registration Dossier
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EC number: 226-403-3 | CAS number: 5394-63-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981-07-31 until 1981-08-14
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No test Guideline is mentioned. Acceptable for reliability but not in detail documented.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Principles of method if other than guideline:
- No further information available.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diketen-Acetone-Adduct
- IUPAC Name:
- Diketen-Acetone-Adduct
- Test material form:
- other: liquid
- Details on test material:
- Liquid samples will be administered as received/undiluted.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: undiluted
- Doses:
- 5000 mg/kg
3200 mg/kg
2000 mg/kg
1300 mg/kg
800 mg/kg - No. of animals per sex per dose:
- 10 male were used for each dose level.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 value of Diketen-Acetone-Adduct is greater than 5000 mg/kg, therefore the test item will be not classified as acute toxic.
- Executive summary:
The study was performed 1981. 10 male Albino rats/Charles River CD (Sprague-Dawley) per dose were used for the test.
The kidney in the survivors was enlarged with moderate dilation of the medullary region. The LD50 value of Diketen-Acetone-Adduct is greater than 5000 mg/kg, therefore the test item will be not classified as acute toxic.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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