Registration Dossier
Registration Dossier
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EC number: 418-140-1 | CAS number: 5117-12-4 ACRYLOYLMORPHOLIN
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to EG B.3 Teil B / OECD 402
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EG B.3 Teil B / OECD 402
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 4-(1-oxo-2-propenyl)-morpholine
- EC Number:
- 418-140-1
- EC Name:
- 4-(1-oxo-2-propenyl)-morpholine
- Cas Number:
- 5117-12-4
- Molecular formula:
- C7H11NO2
- IUPAC Name:
- 1-(morpholin-4-yl)prop-2-en-1-one
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: none
- Details on dermal exposure:
- 24h
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 1260 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 3200 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Body weight gains were reduced on day 8 in most of the animals, especially in that which received 2000 or 3200 mg/kg.
- Gross pathology:
- In the animals which died during the study: unregullar areas of pallor in the liver.
- Other findings:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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