Registration Dossier

Diss Factsheets

Administrative data

First-aid measures

The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Description of first aid measures
General advice:
First Aid responders should pay attention to self-protection and use the recommended protective clothing
Take off contaminated clothing and shoes immediately.
Move out of dangerous area.
Keep warm and in a quiet place.

If inhaled:
Provide fresh air.
If not breathing, give artificial respiration.
Keep the victim calm and in a semi-upright position.
Call a physician immediately.

In case of skin contact:
Wash off immediately with plenty of water for at least 15 minutes.
Call a physician immediately.

In case of eye contact:
Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Call a physician immediately.

If swallowed:
Clean mouth with water and drink afterwards plenty of water.
Never give anything by mouth to an unconscious person.
Do NOT induce vomiting.
Call a physician immediately.
Most important symptoms and effects, both acute and delayed

Symptoms:
headache
Nausea
Dizziness
Unconsciousness
The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Risks:
If swallowed, severe burns in the oral cavity and throat as well as danger of perforation of the digestive tract and stomach.
Indication of any immediate medical attention and special treatment needed

Treatment:
Treat symptomatically.
For specialist advice physicians should contact the Poisons Information Service.

Fire-fighting measures

The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Dry extinguishing media based on NaCl (e.g.Totalit M) or pulverized limestone.

Unsuitable extinguishing media:
Water
Carbon dioxide (CO2)
Foam

Special hazards arising from the substance or mixture

Specific hazards during fire-fighting:
May form toxic gases on heating or in case of fire.
Vapours may form explosive mixture with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.

Advice for firefighters

Special protective equipment for firefighters:
Wear full protective clothing and self-contained breathing ap-paratus.

Further information:
Use water spray to cool unopened containers.
Be aware of a dangerous reaction with water, if the container is ruptured.
Collect contaminated fire extinguishing water separately. This must not be discharged into drains.
Fire residues and contaminated fire extinguishing water

Accidental release measures

The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Personal precautions, protective equipment and emergency procedures

Personal precautions:
Remove all sources of ignition.
Ensure adequate ventilation.
Wear personal protective equipment.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep people away from and upwind of spill/leak.

Environmental precautions

Environmental precautions:
Do not flush into surface water or sanitary sewer system.
Avoid subsoil penetration.

Methods and materials for containment and cleaning up

Methods for cleaning up:
Never allow contact with water.
Cover spilled material with limestone powder.
Pick up and transfer to

Handling and storage

The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Precautions for safe handling

Advice on safe handling:
Handle under inert gas.
Provide sufficient air exchange and/or exhaust in work rooms.
Provide exhaust ventilation close to floor level.
Never allow water to come into contact with the product.
Wear personal protective equipment.
Handle in accordance with good industrial hygiene and safety practice.

Advice on protection against fire and explosion:
Vapours may form explosive mixtures with air.
Vapours are heavier than air and may spread along floors.
Flash back possible over considerable distance.
Keep away from sources of ignition - No smoking.
Take precautionary measures against static discharges.
Use explosion-proof equipment.
Uncleaned empty containers can contain product gases, which form explosive mixtures with air.

Conditions for safe storage, including any incompatibilities
Requirements for storage areas and containers:
Keep under inert gas.
Keep containers tightly closed in a dry, cool and well-ventilated place.
Keep away from heat.
Protect from direct sunlight.
Protect from moisture.
Protect from frost.
Avoid contact with air/oxygen.

Advice on common storage:
Never allow product to get in contact with water during stor-age.
Incompatible with oxidizing agents.
Acids
Other protic substances.

Storage temperature:
> 10 °C
Specific end use(s)

Specific use(s):
Reagent for organic synthesis.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
Shipping information
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE tert-Butylmagnesium chloride, Tetrahydrofuran
Labels:
4.3 (3)
SpecialProvisionsopen allclose all
Shippingopen allclose all
Remarksopen allclose all

Marine transport (UN RTDG/IMDG)

UN number:
The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
Shipping information
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE tert-Butylmagnesium chloride, Tetrahydrofuran
Labels:
4.3 (3)
Remarksopen allclose all

Air transport (UN RTDG/ICAO/IATA)

UN number:
The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).
Shipping information
Proper shipping name and description:
ORGANOMETALLIC SUBSTANCE, LIQUID, WATER-REACTIVE, FLAMMABLE tert-Butylmagnesium chloride, Tetrahydrofuran
Labels:
4.3 (3)
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

The following information applies to the substance in organic solution (see IUCLID 3.4: Information on mixtures).

Engineering measures
Provide sufficient air exchange and/or exhaust in work rooms.
Provide exhaust ventilation close to floor level.
Take precautionary measures against static discharges.
Electrical equipment should be protected to the appropriate standard.
Personal protective equipment

Respiratory protection:
In case of insufficient ventilation wear suitable respiratory equipment.
For short-time or low exposures, use breathing apparatus with a filter.
Recommended Filter type:
A-P2
For intensive or prolonged exposure, use a self-contained breathing apparatus.

Hand protection:
Glove material: Flame retardant gloves
Protective gloves complying with EN 374.
The choice of an appropriate glove does not only depend on its material but also on other quality features and is different from one producer to the other.
The exact break through time can be obtained from the protective glove producer and this has to be observed.
Protective gloves have to be replaced at the first sign of deterioration.

Eye protection:
Eye protection (EN 166)
Tightly fitting safety goggles

Skin and body protection:
Flame retardant, antistatic and chemical resistant protective clothing

Hygiene measures:
Take off contaminated clothing and shoes immediately.
Avoid contact with skin, eyes and clothing.
Do not breathe gas/fumes/vapour/spray.
Keep away from food, drink and animal feedingstuffs.
Smoking, eating and drinking should be prohibited in the
application area.
Wash hands before breaks and at the end of workday.

Protective measures:
Facilities storing or utilizing this material should be equipped with an eyewash facility and safety shower.
Handle in accordance with good industrial hygiene and safety practice.

Control parameters:

Tetrahydrofuran: TWA (2000/39/EC, 2000-06-16): 50 ppm; 150 mg/m3
Tetrahydrofuran: STEL (2000/39/EC, 2000-06-16): 100 ppm; 300 mg/m3

Stability and reactivity

The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Reactivity

Risk of violent reaction.

Chemical stability
Decomposes on heating., Sensitive to air., Decomposition under influence of moisture is highly ac-celerated by heating.

Possibility of hazardous reactions

Hazardous reactions:
May form explosive peroxides.
Reacts violently with water.
In contact with water releases flammable gases which may ignite spontaneously.
Vapours may form explosive mixture with air.

Conditions to avoid

Conditions to avoid:
Keep away

Protect from frost, heat and sunlight.
Protect from moisture.
Static discharge.
Avoid formation of aerosol.

Incompatible materials

Materials to avoid:
Water Acids Oxidizing agents Other protic substances.

Hazardous decomposition products

Risk of decomposition.:
Decomposes in contact with water.

Isobutane

Thermal decomposition:
To avoid thermal decomposition, do not overheat.

Disposal considerations

The following information applies to the substance in THF (see IUCLID 3.4: Information on mixtures). The substance is also placed on the market in other solvents (see IUCLID 1.2: Composition / Additives).

Waste treatment methods

Product:
Dispose of in accordance with local regulations.

Contaminated packaging:
Refer to manufacturer/supplier for information on recov-ery/recycling.

Waste Code:
Waste codes should be assigned by the user, preferably