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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1968
Report date:
1968
Reference Type:
other: TSCAT
Title:
TSCAT
Author:
US EPA
Year:
1992
Bibliographic source:
TSCATS: 8ECP, Doc. I.D: 88-920003052, 27.5.92; submitting organisation: BASF AG

Materials and methods

Principles of method if other than guideline:
Six rats per dose were exposed to a test substance concentration of ca. 173 ppm and 185 ppm for 1 hour by inhalation. In addition 6 rats were exposed to ca. 265 ppm for 30 minutes. The rats were then observed for 7 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloropropionyl chloride
EC Number:
210-890-4
EC Name:
3-chloropropionyl chloride
Cas Number:
625-36-5
Molecular formula:
C3H4Cl2O
IUPAC Name:
3-chloropropanoyl chloride
Details on test material:
- Name of test material (as cited in study report): beta-Chlorpropionylchlorid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: air
Details on inhalation exposure:
The vapors were generated by bubbling 10 L/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder and then diluted with 480 L/h air.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
h
Remarks on duration:
30 min and 1 h
Concentrations:
173 ppm / 0.90 mg/L (1 hour), 185 ppm / 0.96 mg/L (1 hour), and 265 ppm / 1.38 mg/L (30 min)
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: not specified
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Statistics:
no data

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LC50
Effect level:
< 0.9 mg/L air
Based on:
test mat.
Exp. duration:
1 h
Mortality:
- 173 ppm: 5 out of 6 rats died
- 185 ppm: 4 out of 6 rats died
- 265 ppm: 3 out of 6 rats died
Clinical signs:
other: Attempts to escape, after 3 minutes dyspnea, irritation of the mucous membrane, gasping, surviving animals showed accelerated breath for several days.
Body weight:
no data
Gross pathology:
- Animals that died: pulmonary edema
- Sacrificed animals: sporadic chronic bronchitis

Applicant's summary and conclusion