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EC number: 613-239-6
CAS number: 63502-25-0
Skin reactions after
24h after injection
48h after injection
0 = No erythema
0 = No oedema
Intradermal injections (Readings Day 3)
Epidermal exposure (Reading day 10)
1:1 Mixture of FCA and water for injection
1:1 Mixture of FCA and vehicle
signs of necrosis (Ø mm)
FCA = Freunds' Complete
1 = Slight erythema
Test concentration 100%
s. Scaliness, k. Scabs
0 = No visible change
1 = Discrete or patch
2 = Moderate and
3 = Moderate erythema
4 = Intense erythema
Body weight (g)
Sex / group
In a dermal
sensitization study with Phosphonium,
tetrakis(hydroxymethyl)-, sulphate (2:1) (salt), polymer with urea.
female albino guinea pigs (10 treated females + 5 controls) were tested
in compliance with OECD 406, method B6 in Commission Directive
84/449/EEC and in compliance with GLP.
Based on the results of
the pilot tests, the concentrations of test material were 0.1 % (w/v)
for the intradermal applications of the induction phase, respectively,
and 100 % in the challenge phase.
10/10 animals were
tetrakis(hydroxymethyl)-, sulphate (2:1) (salt), polymer with urea
was therefore considered to be skin sensitizer cat 1A.
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