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EC number: 205-275-2 | CAS number: 137-05-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
- Type of study / information:
- Airborne Concentrations of Ethyl and Methyl Cyanoacrylate in the Workplace
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted at an adhesive production facility in Puerto Rico. The air sampling programm was conducted in an attempt to characterize peak airborne concentrations of ECA for those tasks associated with the highest probability of worker exposure. For more continuous tasks, longer samples were collected.The samples were analysed using the OSHA 55 procedure.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Mecrilate
- EC Number:
- 205-275-2
- EC Name:
- Mecrilate
- Cas Number:
- 137-05-3
- Molecular formula:
- C5H5NO2
- IUPAC Name:
- methyl 2-cyanoprop-2-enoate
- Details on test material:
- MCA was collected together with ECA in the mixing areas. Both are clear colorless liquids with strong acrid odors at airborne concentrations above 10 ppm. They react readily with water to form a solid polymer.
METHYL CYANOACRYLATE (MCA):
- CAS 137-05-3
- MW 111.1
- Boiling point 48-49°C at 0.33-0.36 kPa
- Vapor pressure: < 0.27 kPa at 25°C
- Odor threshold 1-5 ppm
- Relative density 1.10959
ETHYL CYANOACRYLATE (ECA):
- CAS 7085-85-0
- MW 125.1
- Boiling point 54-56°C at 0.21-0.40 kPa
- Vapor pressure: < 0.27 kPa at 25°C
- Relative density 1.05
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- For this study, sample collection was performed using Tenax collection tubes. Each sample was desorbed in a 44:56 (acetonitrile/0.2% phosphoric acid in water) solution immediately after collection and analyzed within 24 -48 hours of sample collection by HPLC with UV detector.
A total of 172 personal and area samples were collected at the plant. 10 blank samples were used for quality control purposes. Of the 162 remaining samples, 152 were analyzed for ethyl cyanoacrylate (93%) and 10 were analyzed for methyl cyanoacrylate (7%).
The majority of the samples were collected in the bottling and packaging area (71%) and the mixing area (19%), in which most of the workers are located.
Air sampling pumps were worn on the belts of individuals or mounted in areas of interest. The sorbent tubes were placed in the breathing zone of individuals for personal samples, on in either worst case or representative zones for area samples. - Exposure assessment:
- measured
- Details on exposure:
- Type of exposure measurement:
The air sampling programm was conducted in an attempt to characterize peak (7-20 min, short term) airborne concentrations of ECA for those tasks associated with the highest probability of worker exposure. For more continuous tasks, longer samples (30-130 min, some 6-8 h) were collected.
Results and discussion
- Results:
- The results are listed in the table below.
Any other information on results incl. tables
ECA/MCA Air Sampling Data for the Mixing Operator
|
|
|
Range |
|
|
Sampling Activity/Sampling Period |
Sample Type |
Number of Samples |
Minimum |
Maximum |
Mean |
Task 1: Loading vessels |
|
|
|
|
|
Peak (5-15 min) |
Personal |
3 |
<0.0057 |
0.067 |
0.039 |
|
Area |
3 |
0.055 |
0.13 |
0.084 |
Interval (25-130 min) |
Personal |
3 |
0.05 |
0.09 |
0.072 |
Task 2: Adding solid additives |
|
|
|
|
|
Peak (5-15 min) |
Personal |
3 |
0.012 |
0.180 |
0.071 |
|
Area |
1 |
- |
- |
0.074 |
Task 3: Drum loading |
|
|
|
|
|
Peak (5-15 min) |
Personal – with LEV |
1 |
- |
- |
0.067 |
|
Personal –without LEV |
10 |
0.058 |
1.5 |
0.650 |
|
Area – with LEV |
1 |
- |
- |
0.100 |
|
Area – Without LEV |
4 |
0.164 |
0.9 |
0.470 |
|
Area – worst case |
4 |
0.45 |
2.2 |
1.360 |
Interval (25-130 min) |
Personal – with LEV |
1 |
- |
- |
0.028 |
|
Personal –without LEV |
1 |
- |
- |
0.140 |
Task 4: Decanting |
|
|
|
|
|
Peak (5-15 min) |
Personal |
1 |
- |
- |
0.16 |
Task 5: Discarding off-spec product |
|
|
|
|
|
Peak (5-15 min) |
Personal |
2 |
<0.005 |
0.11 |
0.056 |
All Tasks |
|
|
|
|
|
TWA (360-480 min) |
Personal |
1 |
- |
- |
0.069 |
|
Area |
2 |
0.016 |
0.02 |
0.018 |
Note: All units in ppm. Area worst case = samples collected 2-4 inches above drum and are not representative of worker exposure. – Not applicable
ECA Air Sampling Data for Bottling and Packaging Operator
|
|
|
Range |
|
|
|
SamplingActivity/Sampling Period |
Sample Type |
Number of Samples |
Minimum |
Maximum |
Mean |
Standard Deviation |
Task 1: Bottling, packaging, and labeling |
|
|
|
|
|
|
Peak (5-15 min) |
Personal |
19 |
0.01 |
0.087 |
0.049 |
0.021 |
Interval (25-130 min) |
Personal |
60 |
<0.001 |
0.089 |
0.040 |
0.016 |
|
Area |
4 |
0.016 |
0.063 |
0.047 |
0.021 |
Peak Task 2: Product line change |
|
|
|
|
|
|
Peak (5-15 min) |
Personal |
6 |
0.023 |
0.11 |
0.084 |
0.033 |
Interval (25-130 min) |
Personal |
1 |
- |
- |
0.260 |
- |
Task 3: Machine calibration |
|
|
|
|
|
|
Peak (5-15 min) |
Personal |
1 |
- |
- |
<0.0039 |
- |
All Tasks |
|
|
|
|
|
|
TWA (360-480 min) |
Personal |
10 |
0.014 |
0.048 |
0.035 |
0.010 |
|
Area |
7 |
0.019 |
0.056 |
0.034 |
0.012 |
Note: All units in ppm. – Not applicable
Applicant's summary and conclusion
- Conclusions:
- The air sampling methods used in the study provide reliable results that are consistent with other sampling programs and are superior to the OSHA sampling methods. The results of this air sampling program indicate that when handled at room temperature, both methyl 2-cyanoacrylate (MCA) and ethyl-cyanoacrylate (ECA) produce airborne concentrations that are nearly always less than about 0.1 ppm, which is much less than the threshold of irritation.
- Executive summary:
A survey was conducted of persons who manufacture, mix, bottle, and package methyl 2-cyanoacrylate (MCA) and ethyl-cyanoacrylate (ECA). Airborne concentrations of these cyanoacrylates also were measured during waste-handling operations. During a 1 -week period, 162 personal and area samples were collected. About 90% of the samples were analyzed for ECA (the predominant adhesive being manufactured at the facility). About 50% of these samples had collection periods of 15 min or less, the remainder of 15 to 240 min. Some 8 -hour time weighted average (TWA) samples were also included. For the sampling process, Tenax tubes were used with subsequent analysis by HPLC. Most samples were collected where the highest exposure was likely (e.g. during mixing, bottling, and packaging).
Peak concentrations of ECA for the mixing operators ranged from 0.039 ppm to 0.650 ppm, while various 10-min to 1 -hour activities were performed, with a TWA concentration of 0.07 ppm. Personal short-term airborne concentrations of ECA for bottling and packaging workers (n = 60) were 0.040 ppm ± 0.016 ppm (mean ± standard deviation), with similar 8 -hour TWA concentrations due to the continuous process of bottling and packaging. Other personal samples were not significantly different. The area samples were normally within a factor of 2 of the peak personal sampling results.
These data indicate that, when handled at room temperature and relative humidity range from 40 -69%, both MCA and ECA produce airborne concentrations that are nearly always less than about 0.1 ppm, which is less than the threshold of irritation.
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