N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide

Short-term toxicity to aquatic invertebrates

Description of key information

A study (CERI, 2010) was conducted according to OECD Guideline 202 in order to confirm the effect of the test item on the test organisms below the solubility of the test item in dilution water. As a result, pH unadjusted 48 -hour EC50 was 15 mg/L. In the highest concentration level, since pH exceeded 9, the test concentration division which performed pH adjusted levels prepared separately. As a result, pH adjusted 48 -hour EC50 was 16 mg/L. From this result, it is guessed that pH is not participating in the toxicity over the Daphnia magna of a test item. The concentration of the test item in the test solution during exposure was maintained at that of the start of the exposure. The environmental conditions were within the suitable range; therefore, it is concluded that this study complied with the applied test guidelines. 
In a second study Daphnia magna were exposed to the test article for 48 hours at the nominal concentrations of 1, 10, 50, 100 and 250 mg of test article per liter of test medium. Measurements of pH, dissolved oxygen and temperature were performed at the beginning and at the end of the test for each test medium. Each test medium was sampled at the start and at the end of the test. 
The following results were obtained from the study for the test item: EC50 (24 h) > 250 mg/l, EC50 (48 h) = 250 mg/l, EC0 < 1 mg/l and EC100 > 250 mg/l. 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

15 mg/L