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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

The available read across data and available weight of evidence demonstrate that Isohexadecane is highly unlikely to be carcinogenic and is not classifiable as a carcinogen. Further testing is not required under Annex XI, section 1.2.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Link to relevant study records
Reference
Endpoint:
carcinogenicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
carcinogenicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Link to relevant study records
Reference
Endpoint:
carcinogenicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

These findings do not warrant the classification of Isohexadecane as a carcinogen under the CLP Regulation (EC) 1272/2008 on classification, labeling and packaging of substances and mixtures.

Additional information

Isohexadecane is not genotoxic and is not classifiable as a mutagen based upon the results of reliable read across in vitro and in vivo studies. In bacterial reverse mutation studies, Isohexadecane and structural analogue Hydrocarbons, C14-C17, n-alkanes, <2% aromatics were not mutagenic in the presence or absence of metabolic activation. In mammalian cells in vitro there were no mutagenic, clastogenic or aneugenic effects reported in read-across from studies on hydrodesulfurized kerosene kerosene: a negative chromosome aberration (Human Peripheral Lymphocyte Chromosomal Aberration Test, Chinese Hamster Ovary Sister Chromatid Exchange Assay).