Registration Dossier
Registration Dossier
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EC number: 275-156-8 | CAS number: 71048-82-3
Endpoint summary
Administrative data
Description of key information
Additional information
Two studies are available for the short-term toxicity of delta-damascone to fish. One study is a semi-static GLP-compliant OECD Guideline 203 study with medaka (Oryzias latipes) (Kurume Laboratory, 2009). The concentrations were analytically verified, the 96-h LC50 was 0.97 mg/L based on measured concentrations. The other study is also a semi-static GLP-compliant OECD 203 study with the same species. The 96-h LC50 was 0.977 mg/L based on nominal concentrations (Kurume Laboratory, 2007b). The most critical value is used in the assessment, which is the 96-h LC50 of 0.97 mg/L.
No data is available on long-term toxicity in fish.
No short-term study on invertebrates is available, but instead a semi-static GLP compliant, OECD Guideline 211 study is available regarding long-term toxicity of delta-damascone to Daphnia magna (Huntingdon Life Sciences Ltd, 2009c). The concentrations were analytically verified and the 21-d NOEC for reproduction was 0.35 mg/L. This value is used in the assessment.
One GLP compliant OECD Guideline 201 study is available for growth inhibition of delta-damascone to Pseudokirchneriella subcapitata (Huntingdon Life Sciences Ltd, 2009d). The concentrations were analytically verified. The 72-h EbC50 was 2.47 mg/L, the 72-h ErC50 and NOErC were 4.54 mg/L and 0.883 mg/L, respectively. The effect concentrations based on growth rate are used in the assessment.
One GLP-compliant OECD Guideline 209 respiration inhibition study with micro-organisms is available for delta-damascone (Huntingdon Life Sciences Ltd, 2009e). The 3-h EC50 was 241 mg/L, this value is used in the assessment.
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