Registration Dossier
Registration Dossier
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EC number: 232-259-2 | CAS number: 7803-49-8
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Remarks:
- acute
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Methodological deficiencies, documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Neurotoxicity of sodium Azide and Nitric Oxide
- Author:
- Smith, R.P., et al.
- Year:
- 1 991
- Bibliographic source:
- Fundam. Appl. Toxicol., 17, 120-127
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydroxylamine
- EC Number:
- 232-259-2
- EC Name:
- Hydroxylamine
- Cas Number:
- 7803-49-8
- Molecular formula:
- H3NO
- IUPAC Name:
- hydroxylamine
- Details on test material:
- - Name of test material (as cited in study report): hydroxylamine
Constituent 1
Test animals
- Species:
- other: mica and rats
- Strain:
- other: CD-1 for mice, no data for rats
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories
- Weight at study initiation: 250-300 g
- Diet: ad libitum
- Water: tap water ad libitum
Administration / exposure
- Route of administration:
- other: intra-cerebroventricular injection
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- no data
- Frequency of treatment:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
22 mmol/kg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 5 (males only)
- Control animals:
- no
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Any other information on results incl. tables
Comparative study with azide and nitric oxide included: All rats (5/5) experienced mild and severe convulsions when HA (22 mmol/kg) was applied by intra-cerebroventricular injection of HA. The results suggest that hydroxylamine is inactivated in blood by virtue of the reaction with hemoglobin, and, therefore, fails to penetrate into the central nervous system in effective concentrations. However, when placed in the brain, hydroxylamine produced seizures perhaps by virtue of the conversion to nitric oxide which also produced seizures in lower doses.
Applicant's summary and conclusion
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