4-methylanisole

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May 10, 2017 to June 07, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Media:

soil

Specific details on test material used for the study:

Name (as stated in the report): Cresyl Methyl Ether Para
Natch No.: VE00470042
Expiration date: November 24, 2018

Radiolabelling:

no

Test temperature:

The determination was performed at 35 °C (temperature of the column), but the value obtained above can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log KOC values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way.

Details on study design: HPLC method:

HPLC equipment: Perkin Elmer (series 200) HPLC system comprising:
- a high pressure pump (module N2910102, serial number: 291N8051901A)
- an auto-sampler (module N2930100, serial number: 293N8052404A)
- a column compartment (module N2601581, serial number: OVH0802151130)
- a refractive index detector (series 200a, serial number 125829).
- Column: 250 mm x 4.6 mm, Nucleodur 100-5 CN-RP (Macherey-Nagel), serial number: E15120578, batch 34514011
- Mobile phase: methanol / water 55/45 (v/v)
- Flow rate: 1.0 ml/min.
- Column temperature: 35 °C
- Injected volume: 100 µl

Key result

Sample No.:

#1

Type:

log Koc

Value:

2.6 dimensionless

Temp.:

35 °C

Details on results (HPLC method):

The chromatograms of Cresyl Methyl Ether Para show one peak at an average retention time of 5.737 minutes, corresponding to an adsorption coefficient (log value) of 2.6.

Validity criteria fulfilled:

yes

Conclusions:

The chromatograms of Cresyl Methyl Ether Para show one peak at an average retention time of 5.737 minutes, corresponding to an adsorption coefficient (log value) of 2.6.

Executive summary:

The Adsorption coefficient (Koc) on soil and on sewage sludge of Cresyl Methyl Ether Para was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 121.

 

The result is: Adsorption coefficient (Koc) of Cresyl Methyl Ether Para: log Koc = 2.6

Description of key information

The Adsorption coefficient (Koc) on soil and on sewage sludge of Cresyl Methyl Ether Para was determined by the Reverse Phase High Performance Liquid Chromatographic Method according to the OECD Guidelines for Testing of Chemicals, Method No. 121.

The determination was performed at 35°C (column temperature), however the values can be considered to represent the values at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Koc values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way. The log Koc of Cresyl Methyl Ether Para was determined to be 2.6, equivalent to a Koc of 398

Key value for chemical safety assessment

Koc at 20 °C:

398