Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethylamine
EC Number:
200-574-4
EC Name:
Phenethylamine
Cas Number:
64-04-0
Molecular formula:
C8H11N
IUPAC Name:
2-phenylethanamine
Test material form:
liquid
Details on test material:
Name of the test substance used in the study report: 2-Phenylethylamin

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eye of the same animal
Amount / concentration applied:
0.05 ml
Duration of treatment / exposure:
1 h
Observation period (in vivo):
8 d
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Results
Irritation parameter:
other:
Time point:
24/48/72 h
Reversibility:
not reversible
Remarks on result:
not determinable
Remarks:
after application of the test substance, the whole eyes were destroyed (development of a staphyloma)
Irritant / corrosive response data:
Already after 1 hour, the eyes were corroded.

Applicant's summary and conclusion

Interpretation of results:
Category 1 (irreversible effects on the eye) based on GHS criteria