Registration Dossier
Registration Dossier
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EC number: 200-574-4 | CAS number: 64-04-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Phenethylamine
- EC Number:
- 200-574-4
- EC Name:
- Phenethylamine
- Cas Number:
- 64-04-0
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2-phenylethanamine
- Test material form:
- liquid
- Details on test material:
- Name of the test substance used in the study report: 2-Phenylaethylamin
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- ca. 1 ml
- Duration of treatment / exposure:
- 1 min, 5 min, 15 min, 20 h
- Observation period:
- 8 d
- Number of animals:
- 4
- Details on study design:
- Application area: 2.5 x 2.5 cm
The test substance was wash off with Lutrol.
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 1, 5 and 15 min
- Score:
- 3
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Already after 1min exposure, severe (not relocatable) necrosis was observed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
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