Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethylamine
EC Number:
200-574-4
EC Name:
Phenethylamine
Cas Number:
64-04-0
Molecular formula:
C8H11N
IUPAC Name:
2-phenylethanamine
Test material form:
liquid
Details on test material:
Name of the test substance used in the study report: 2-Phenylaethylamin

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
ca. 1 ml
Duration of treatment / exposure:
1 min, 5 min, 15 min, 20 h
Observation period:
8 d
Number of animals:
4
Details on study design:
Application area: 2.5 x 2.5 cm
The test substance was wash off with Lutrol.

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 1, 5 and 15 min
Score:
3
Reversibility:
not reversible
Irritant / corrosive response data:
Already after 1min exposure, severe (not relocatable) necrosis was observed.

Applicant's summary and conclusion

Interpretation of results:
Category 1A (corrosive) based on GHS criteria