Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1969
Report date:
1969

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no
Test type:
other: Inhalation hazard test

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethylamine
EC Number:
200-574-4
EC Name:
Phenethylamine
Cas Number:
64-04-0
Molecular formula:
C8H11N
IUPAC Name:
2-phenylethanamine
Test material form:
liquid
Details on test material:
Name of the test substance used in the study report: 2-Phenylethylamin

Test animals

Species:
rat
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Remarks on duration:
3 and 8 h
Concentrations:
Saturated vapour concentration 2 mg/L
No. of animals per sex per dose:
3 h: 12
8 h: 6

Results and discussion

Mortality:
3 h: 0/12
8 h: 1/6
Clinical signs:
other: severe attempts to escape, severe mucosal irritations, dyspnea
Gross pathology:
nothing abnormal detected

Applicant's summary and conclusion