Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.

Key value for chemical safety assessment

Additional information

The toxicity of phenethalamine to aquatic microorganisms was investigated with a growth inhibition test conducted according to DIN 38412, part 8, with Pseudomonas putida as test species (BASF AG, 1987 -10 -16). The non-neutralised, nominal concentrations were 0 (control), 100, 200, 300, 400 and 500 mg/L.

Based on nominal test concentrations, the 17-h EC10 was determined to be 242.5 mg/L for non-neutralised test solutions (17-h EC50 = 270 mg/L). These data are considered as the key study. This study was chosen as key study because the lowest EC10 and EC50 were determined.

In a second test according to DIN 38412, part 8, with Pseudomonas putida as test species (BASF AG, 1987 -10 -15) the 17 -h EC10 was determined to be 313.3 mg/L (17 -h EC50 = 397.7).

In both studies the test concentrations were not analytically verified, but are assumed to be stable due to the low n-octanol/water partition coefficient (log Kow = -1.35), the high water solubility (WS = 1.0E+06 mg/L at 25 °C), vapour pressure (VP = 54.5 Pa at 25°C) and the low Henry´s law constant (HLC, uncharged: 8.23E-02 Pa*m3/mol) of the chemical.

Additionally, in an OECD 209 guideline study the 30 -min EC20 was determined to be >2223 mg/L (BASF AG, 1985). However, the study was conducted with activated industrial sludge.

In conclusion, the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.